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Recently, three new axes have been identified, emphasizing the role of the kidney in this picture (22): The ACE2/ANG(1-7)/Mas receptor pathway (23, 24): Ang-(1-7) binds to the G protein-coupled receptor Mas, which is expressed in renal proximal tubular cells, afferent arterioles, cardiac myocytes, and neuronal cells

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So, functionalization approaches of NPs based on cationic proteins and short amphipathic/cationic cell penetrating peptides (CPP), such as Syn-B-based vectors (i.e., a peptide derived from an antimicrobial peptide with high affinity for biological membranes) (Kokryakov et al., 1993) or TAT peptides (i.e., derived from the transcription activating factor of human immunodeficiency virus) (Vivs et al., 1997), are considered the most suitable strategies for brain drug delivery